abstract：BACKGROUND AND PURPOSE:Sleep-disordered breathing (SDB) represents a risk factor for cardiovascular morbidity after a cerebral ischemic event (acute ischemic event, ischemic stroke, or transient ischemic attack). In the present study, endothelial function and arterial stiffness were analyzed in patients who experienced...

journal_title：Stroke

authors： Cereda CW,Tamisier R,Manconi M,Andreotti J,Frangi J,Pifferini V,Bassetti CL

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Most randomized controlled trials of venous thromboembolism prophylaxis have focused on reduction of deep vein thrombosis, predominantly asymptomatic deep vein thrombosis, detected on imaging. We aimed to estimate the effects of graduated compression stockings on venous thromboembolism events, su...

journal_title：Stroke

authors： CLOTS Trials Collaboration.,Dennis M,Sandercock P,Reid J,Graham C,Murray G,Venables G,Rudd A,Bowler G

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Endovascular therapy has increasingly become the most common treatment for unruptured cerebral aneurysms in the United States. We evaluated a national, multi-hospital database to examine recent utilization trends and compare periprocedural outcomes between clipping and coiling treatments of unrup...

journal_title：Stroke

authors： McDonald JS,McDonald RJ,Fan J,Kallmes DF,Lanzino G,Cloft HJ

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis. METHODS:In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined...

journal_title：Stroke

authors： Endo K,Kario K,Koga M,Nakagawara J,Shiokawa Y,Yamagami H,Furui E,Kimura K,Hasegawa Y,Okada Y,Okuda S,Namekawa M,Miyagi T,Osaki M,Minematsu K,Toyoda K

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Parental stroke has been related to an increased risk of stroke in the offspring. This study examines whether parental stroke is also associated with increased vascular brain injury and poorer cognitive performance among offspring free of clinical stroke. METHODS:Multivariable regression analyse...

journal_title：Stroke

authors： Weinstein G,Beiser AS,Au R,Decarli C,Wolf PA,Seshadri S

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pediatric stroke, birth to 18 years, is a significant cause of long-term disability in the United States; however, there is currently little experimental data on the pathophysiology of childhood stroke owing to lack of animal models. We developed a novel mouse model of experimental childhood-onse...

journal_title：Stroke

authors： Herson PS,Bombardier CG,Parker SM,Shimizu T,Klawitter J,Klawitter J,Quillinan N,Exo JL,Goldenberg NA,Traystman RJ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial. METHOD...

journal_title：Stroke

authors： Morrow DA,Alberts MJ,Mohr JP,Ameriso SF,Bonaca MP,Goto S,Hankey GJ,Murphy SA,Scirica BM,Braunwald E,Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering Committee and Investigators

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to evaluate the diagnostic accuracy of ultrasound criteria for recanalization during real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures in acute ischemic stroke patients in an international, multicenter study. METHODS:Consecutive acute ischemic stroke pa...

journal_title：Stroke

authors： Tsivgoulis G,Ribo M,Rubiera M,Vasdekis SN,Barlinn K,Athanasiadis D,Bavarsad Shahripour R,Giannopoulos S,Stamboulis E,Harrigan MR,Molina CA,Alexandrov AV

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The best management of patients with unruptured brain arteriovenous malformations (BAVM) is controversial. In this study, we analyzed the stroke rate and functional outcomes of patients having stereotactic radiosurgery (SRS) for unruptured BAVM using the same eligibility criteria and primary end ...

journal_title：Stroke

authors： Pollock BE,Link MJ,Brown RD

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle cerebral artery occlusion. We hypothesized that this sign is correlated with improved functional outcome in patients with middle cereb...

journal_title：Stroke

authors： Ichijo M,Miki K,Ishibashi S,Tomita M,Kamata T,Fujigasaki H,Mizusawa H

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Epidemiological studies have shown mixed findings on the association between hypertension and stroke in the oldest old. Heterogeneity of the populations under study may underlie variation in outcomes. We examined whether the level of physical and cognitive function moderates the association betwe...

journal_title：Stroke

authors： Sabayan B,van Vliet P,de Ruijter W,Gussekloo J,de Craen AJ,Westendorp RG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Alberta Stroke program early CT score (ASPECTS) is a semiquantative scale for estimating extent and distribution of early ischemic changes within the MCA territory in the acute stroke setting. Good interobserver agreement of total ASPECTS is demonstrated for noncontrast CT (NCCT) and other im...

journal_title：Stroke

authors： Finlayson O,John V,Yeung R,Dowlatshahi D,Howard P,Zhang L,Swartz R,Aviv RI

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:This systematic review summarizes the effectiveness of mirror therapy for improving motor function, activities of daily living, pain, and visuospatial neglect in patients after stroke. METHODS:We searched the Cochrane Stroke Group’s Trials Register (June 2011), the Cochrane Central Register of Controlled Tr...

journal_title：Stroke

authors： Thieme H,Mehrholz J,Pohl M,Behrens J,Dohle C

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our goal was to compare outcomes of patients with proximal middle cerebral artery occlusions treated with intravenous tissue plasminogen activator (tPA) with those of patients treated with stent-based thrombectomy (SBT). METHODS:Patients with proximal middle cerebral artery occlusions included i...

journal_title：Stroke

authors： Leker RR,Eichel R,Gomori JM,Ramirez de Noriega F,Ben-Hur T,Cohen JE

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to determine the incidence of adult cerebral venous thrombosis. METHODS:A retrospective cross-sectional study was conducted among all 19 hospitals located in 2 Dutch provinces serving 3.1 million people. Adult cerebral venous thrombosis cases diagnosed between Janua...

journal_title：Stroke

authors： Coutinho JM,Zuurbier SM,Aramideh M,Stam J

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Angiotensin II produces oxidative stress and endothelial dysfunction in cerebral arteries, and angiotensin II type I receptors may play a role in longevity and vascular aging. Angiotensin-converting enzyme type 2 (ACE2) converts angiotensin II to angiotensin (1-7) and thus, may protect against ef...

journal_title：Stroke

authors： Peña Silva RA,Chu Y,Miller JD,Mitchell IJ,Penninger JM,Faraci FM,Heistad DD

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The contribution of genetics to stroke risk, and whether this differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis allows heritability to be assessed from genomewide association study (GWAS) data. Previous candidate gene studies have identified many associati...

journal_title：Stroke

authors： Bevan S,Traylor M,Adib-Samii P,Malik R,Paul NL,Jackson C,Farrall M,Rothwell PM,Sudlow C,Dichgans M,Markus HS

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Earlier tissue-type plasminogen activator (tPA) treatment for acute ischemic stroke increases efficacy, prompting national efforts to reduce door-to-needle times. We used lean process improvement methodology to develop a streamlined intravenous tPA protocol. METHODS:In early 2011, a multidiscipl...

journal_title：Stroke

authors： Ford AL,Williams JA,Spencer M,McCammon C,Khoury N,Sampson TR,Panagos P,Lee JM

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The modified Rankin Scale (mRS) is the recommended functional outcome assessment in stroke trials. Utility of mRS may be limited by interobserver variability. prestroke function, described using mRS, is often used as trial entry criterion. We assessed the reliability and validity of prestroke mRS...

journal_title：Stroke

authors： Fearon P,McArthur KS,Garrity K,Graham LJ,McGroarty G,Vincent S,Quinn TJ

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hemodynamic properties of brain arteriovenous malformations (AVMs) with risk factors for a future hemorrhage are essentially unknown. We hypothesized that AVMs with anatomic properties, which are associated with an increased rupture risk, exhibit different hemodynamic characteristics than those w...

journal_title：Stroke

authors： Illies T,Forkert ND,Saering D,Wenzel K,Ries T,Regelsberger J,Wegscheider K,Fiehler J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The prevalence of silent brain infarcts varies from 8% to 28% in the general elderly population. Silent brain infarcts are associated with increased risk of subsequent stroke and cognitive dysfunction. By definition, silent strokes lack clinically overt stroke-like symptoms and fail to come to cl...

journal_title：Stroke

authors： Saini M,Ikram K,Hilal S,Qiu A,Venketasubramanian N,Chen C

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In acute stroke patients with intracranial vessel occlusion, angiographic demonstration of antegrade contrast opacification distal to the occlusion site (termed the "clot outline sign") has been associated with higher rates of vessel recanalization. We sought to determine whether antegrade flow c...

journal_title：Stroke

authors： Frölich AM,Psychogios MN,Klotz E,Schramm R,Knauth M,Schramm P

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...

journal_title：Stroke

authors： Zhou X,Chen J,Li Q,Ren G,Yao G,Liu M,Dong Q,Guo J,Li L,Guo J,Xie P

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poststroke cognitive decline and white matter lesions (WML) are related to poor poststroke survival. Whether cognitive reserve as reflected by educational history associates with cognitive decline, recurrent strokes, and poststroke mortality independent of WML is not known. METHODS:A total of 48...

journal_title：Stroke

authors： Ojala-Oksala J,Jokinen H,Kopsi V,Lehtonen K,Luukkonen L,Paukkunen A,Seeck L,Melkas S,Pohjasvaara T,Karhunen P,Hietanen M,Erkinjuntti T,Oksala N

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to investigate whether the Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are associated with cortical volume and thickness. METHODS:Consecutive subjects participating in a prospective cohort study of aging and mild cognitive impair...

journal_title：Stroke

authors： Cardenas VA,Reed B,Chao LL,Chui H,Sanossian N,DeCarli CC,Mack W,Kramer J,Hodis HN,Yan M,Buonocore MH,Carmichael O,Jagust WJ,Weiner MW

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We compared among young patients with ischemic stroke the distribution of vascular risk factors among sex, age groups, and 3 distinct geographic regions in Europe. METHODS:We included patients with first-ever ischemic stroke aged 15 to 49 years from existing hospital- or population-based prospec...

journal_title：Stroke

authors： Putaala J,Yesilot N,Waje-Andreassen U,Pitkäniemi J,Vassilopoulou S,Nardi K,Odier C,Hofgart G,Engelter S,Burow A,Mihalka L,Kloss M,Ferrari J,Lemmens R,Coban O,Haapaniemi E,Maaijwee N,Rutten-Jacobs L,Bersano A,Cereda

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is no...

journal_title：Stroke

authors： Söderholm M,Zia E,Hedblad B,Engström G

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Enhanced angiogenesis facilitates neurovascular remodeling processes and promotes brain functional recovery after stroke. Previous studies from our laboratory demonstrated that valproate (VPA), a histone deacetylase inhibitor, protects against experimental brain ischemia. The present study invest...

journal_title：Stroke

authors： Wang Z,Tsai LK,Munasinghe J,Leng Y,Fessler EB,Chibane F,Leeds P,Chuang DM

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays a role in brain injury after global cerebral ischemia. METHODS:Adult male wild-type or PAR-1 knock...

journal_title：Stroke

authors： Wang J,Jin H,Hua Y,Keep RF,Xi G

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Maternal cigarette smoking increases the risk of neonatal morbidity. We tested the hypothesis that perinatal nicotine exposure causes heightened brain vulnerability to hypoxic-ischemic (HI) injury in neonatal rats through aberrant expression patterns of angiotensin II type 1 (AT(1)R) and type 2 (...

journal_title：Stroke

authors： Li Y,Xiao D,Dasgupta C,Xiong F,Tong W,Yang S,Zhang L

更新日期：2012-09-01 00:00:00

abstract：:The European Stroke Organisation held its first European Stroke Science Workshop in Garmisch-Partenkirchen, Germany (December 15-17, 2011). Stroke experts based in Europe were invited to present and discuss their current research. The scope of the workshop was to review the most recent findings of selected topics in s...

journal_title：Stroke

authors： Mattle HP,Brainin M,Chamorro A,Diener HC,Hacke W,Leys D,Norrving B,Ward N

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clear elucidation of the exact pathophysiological mechanisms of motor weakness in patients with subarachnoid hemorrhage has not yet been achieved. We attempted to investigate injury to the corticospinal tract in patients with subarachnoid hemorrhage using diffusion tensor imaging. METHODS:Twenty...

journal_title：Stroke

authors： Yeo SS,Choi BY,Chang CH,Kim SH,Jung YJ,Jang SH

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT) pilot study showed that early intensive blood pressure-lowering can attenuate hematoma growth in acute intracerebral hemorrhage. The present analysis aimed to determine the treatment effects on hematoma growth by...

journal_title：Stroke

authors： Arima H,Huang Y,Wang JG,Heeley E,Delcourt C,Parsons M,Li Q,Neal B,Chalmers J,Anderson C,INTERACT1 Investigators.

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Posttraumatic stress disorder (PTSD) can be triggered by life-threatening medical events such as strokes and transient ischemic attacks (TIAs). Little is known regarding how PTSD triggered by medical events affects patients' adherence to medications. METHODS:We surveyed 535 participants, age ≥40...

journal_title：Stroke

authors： Kronish IM,Edmondson D,Goldfinger JZ,Fei K,Horowitz CR

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Angiographic vasospasm frequently complicates subarachnoid hemorrhage and has been implicated in the development of delayed cerebral ischemia. Whether large-vessel narrowing adequately accounts for the critical reductions in regional cerebral blood flow underlying ischemia is unclear. We sought t...

journal_title：Stroke

authors： Dhar R,Scalfani MT,Blackburn S,Zazulia AR,Videen T,Diringer M

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain microbleeds (MBs) are considered to be associated with cognitive decline and can be pathologically and topographically classified as cerebral amyloid angiopathy-related (located in lobar regions) and hypertensive microangiopathy-related (located in deep regions). We examined whether differe...

journal_title：Stroke

authors： Yakushiji Y,Noguchi T,Hara M,Nishihara M,Eriguchi M,Nanri Y,Nishiyama M,Hirotsu T,Nakajima J,Kuroda Y,Hara H

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Current US guideline statements regarding primary and secondary cardiovascular risk prediction and prevention use absolute risk estimates to identify patients who are at high risk for vascular disease events and who may benefit from specific preventive interventions. These guidelines do not expli...

journal_title：Stroke

authors： Lackland DT,Elkind MS,D'Agostino R Sr,Dhamoon MS,Goff DC Jr,Higashida RT,McClure LA,Mitchell PH,Sacco RL,Sila CA,Smith SC Jr,Tanne D,Tirschwell DL,Touzé E,Wechsler LR,American Heart Association Stroke Council.,Council on

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of our study was to compare lesion location between moyamoya disease-related intracerebral hemorrhage (MMD-ICH) and primary intracerebral hemorrhage (P-ICH). METHODS:Ninety-three patients each with MMD-ICH and P-ICH were compared. In patients with MMD-ICH, angiographic findings were ...

journal_title：Stroke

authors： Nah HW,Kwon SU,Kang DW,Ahn JS,Kwun BD,Kim JS

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The joint effect of risk factors on the risk of aneurysmal SAH (aSAH) has been studied sparsely. METHODS:We examined the potential synergism between cigarette smoking, hypertension, and regular alcohol consumption and the risk of aSAH in a prospective, population-based cohort of participants fro...

journal_title：Stroke

authors： Lindekleiv H,Sandvei MS,Romundstad PR,Wilsgaard T,Njølstad I,Ingebrigtsen T,Vik A,Mathiesen EB

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Traditional vascular risk factors do not completely explain the asymmetry, racial, and sex differences in carotid artery disease. Carotid anatomy and geometry may play a role in the pathogenesis of internal carotid artery (ICA) stenosis, but their effects are unknown. We hypothesized that carotid...

journal_title：Stroke

authors： Phan TG,Beare RJ,Jolley D,Das G,Ren M,Wong K,Chong W,Sinnott MD,Hilton JE,Srikanth V

更新日期：2012-06-01 00:00:00